(1R)-(+)-莰烷酸合成路线 （共 12 条）
反应条件
water; sodium hydroxide in tetrahydrofuran; methanol T=20 - 25°C; 1 h; Large scale;
参考文献
Ohigashi, Atsushi; Kanda, Atsushi; Moriki, Shigeru; Baba, Yukihisa; Hashimoto, Norio; Okada, Minoru
Organic Process Research and Development, 2013 , vol. 17, # 4 p. 658 - 665
反应条件
1: With phosphorus pentachloride; trichlorophosphate T=0°C; 9 h; RefluxLarge scale; 2: With sulfuric acid in water 8 h; RefluxLarge scale;
参考文献
Ohigashi, Atsushi; Kanda, Atsushi; Moriki, Shigeru; Baba, Yukihisa; Hashimoto, Norio; Okada, Minoru
Organic Process Research and Development, 2013 , vol. 17, # 4 p. 658 - 665
反应条件
hydrogenchloride; sodium carbonate in water 3.5 h; Heating;
参考文献
Kappes, Dag; Gerlach, Hans
Synthetic Communications, 1990 , vol. 20, # 4 p. 581 - 587
反应条件
sulfuric acid Heating;
参考文献
Bowden, Roy D.; Cooper, Robin D. G.; Harris, C. John; Moss, Gerard P.; Weedon, Basil C. L.; Jackman, Lloyd M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 7 p. 1465 - 1474
反应条件
1: 83 percent / 4 M pyridine / benzene / 24 h / 20 °C 2: ZnI2 / 96 h / 20 °C 3: 1.) 1 N KOH; 2.) 40 percent formalin / 1.) water, 20 deg C, 30 min; 2.) water, 20 deg C, 10 min View Scheme
参考文献
Helvetica Chimica Acta, , vol. 66, # 6 p. 1865 - 1871
反应条件
1: Br2 / 23 h / 65 °C 2: water / 2 h / temp. below 30 deg C 3: 68 percent / 1.) Na2CO3, 2.) conc. hydrochloric acid / H2O / 3.5 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 20, # 4 p. 581 - 587
反应条件
1: 85 percent / ice, water / dimethylformamide 2: 87 percent / 0.1N-sulphuric acid / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1465 - 1474
反应条件
1: ethanol / 20 - 80 °C / |Resolution of racemate; |Large scale 2: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 - 25 °C / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 17, # 4 p. 658 - 665
反应条件
1: ZnI2 / 96 h / 20 °C 2: 1.) 1 N KOH; 2.) 40 percent formalin / 1.) water, 20 deg C, 30 min; 2.) water, 20 deg C, 10 min View Scheme
参考文献
Helvetica Chimica Acta, , vol. 66, # 6 p. 1865 - 1871
反应条件
potassium hydroxide; formaldehyd 1.) water, 20 deg C, 30 min; 2.) water, 20 deg C, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Helvetica Chimica Acta, , vol. 66, # 6 p. 1865 - 1871
