3,3,5,5-四碘甲腺乙酸合成路线 （共 8 条）
反应条件
ammonia; iodine in methanol
参考文献
Bridoux, Alexandre; Khan, Riaz A.; Chen, Celei; Cheve, Gwenael; Cui, Huadong; Dyskin, Evgeny; Yasri, Aziz; Mousa, Shaker A.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 871 - 882
反应条件
1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C 1.2: 2 h / 125 °C / Inert atmosphere 2.1: hydrogen / Lindlar catalyst / ethanol 3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C 3.2: 1 h / 20 °C 4.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux 5.1: iodine; ammonia / methanol View Scheme
反应条件
1.1: hydrogen / Lindlar catalyst / ethanol 2.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C 2.2: 1 h / 20 °C 3.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux 4.1: iodine; ammonia / methanol View Scheme
反应条件
1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C 1.2: 2 h / 125 °C / Inert atmosphere 2.1: hydrogen / Lindlar catalyst / ethanol 3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C 3.2: 1 h / 20 °C 4.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux 5.1: iodine; ammonia / methanol View Scheme
反应条件
1: aqueous HI; red phosphorus; acetic acid 2: methanol; aqueous NH3 / anschliessendes Behandeln mit Jod in Methanol View Scheme
参考文献
Biochemical Journal, , vol. 63, p. 601,603
反应条件
1.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C 1.2: 1 h / 20 °C 2.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux 3.1: iodine; ammonia / methanol View Scheme
反应条件
1: KI; aqueous ethanol 2: aqueous HI; red phosphorus; acetic acid 3: methanol; aqueous NH3 / anschliessendes Behandeln mit Jod in Methanol View Scheme
参考文献
Biochemical Journal, , vol. 50, p. 438
反应条件
1: aqueous HI; red phosphorus; acetic acid 2: methanol; aqueous NH3 / anschliessendes Behandeln mit Jod in Methanol View Scheme
参考文献
Biochemical Journal, , vol. 50, p. 438
