4-溴-1,3-苯并二恶唑合成路线 （共 6 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=110°C;
参考文献
Kobayashi, Yuichi; Lalitnorasate, Paveena; Kaneko, Yuki; Kiyotsuka, Yohei; Endo, Yoshiki
Tetrahedron Letters, 2010 , vol. 51, # 46 p. 6018 - 6021
反应条件
sodium hydroxide in dichloromethane; dimethyl sulfoxide
参考文献
US4502882 A1, ;
US4659368 A1, ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=100°C; 12 h;
参考文献
Thibonnet, Jerome; Abarbri, Mohamed; Parrain, Jean-Luc; Duchene, Alain
Tetrahedron, 2003 , vol. 59, # 24 p. 4433 - 4441
反应条件
n-butyllithium in tetrahydrofuran; hexanes T=-78 - 20°C; 3 h;
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2007/96072 A2, 2007 ;
Location in patent: Page/Page column 34 ;
WO 2007/096072 A2
反应条件
1: 1.) tetrakistriphenylphosphine palladium; 2.) 1 M HCl / 1.) toluene, 100 degC, 12 h; 2.) water, rt, 15 min
2: 1.) H2; 2.) (CF3CO)2O / 1.) Pd/C 10percent / 1.) THF; 2.) ClCH2-CH2Cl
View Scheme
参考文献
Thibonnet, Jerome; Abarbri, Mohamed; Parrain, Jean-Luc; Duchene, Alain
Tetrahedron Letters, 1996 , vol. 37, # 42 p. 7507 - 7510
反应条件
copper(l) iodide; zinc diacetate
T=135°C; 36 h; regioselective reaction;
参考文献
Joseph, P.J. Amal; Priyadarshini; Kantam, M. Lakshmi; Sreedhar
Tetrahedron, 2013 , vol. 69, # 38 p. 8276 - 8283
