5-[N-(3,5-二三氟甲基苄基)氨基]-2-甲基四氮唑合成路线 （共 3 条）
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 4 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/73934 A1, 2007 ;
Location in patent: Page/Page column 101 ;
反应条件
1: in toluene
4 h; Molecular sieveHeating / reflux;
2: With sodium tetrahydroborate in ethanol
T=20 - 25°C; 0.5 h;
3: With water; ammonium chloride in ethanol
参考文献
PFIZER PRODUCTS INC.
Patent: WO2006/56854 A1, 2006 ;
Location in patent: Page/Page column 57 ;
反应条件
1: in toluene
0.75 h; Heating / reflux;
2: With sodium tetrahydroborate in ethanol
T=20°C; 4 h;
3: With water; ammonium chloride in ethanol
参考文献
NOVARTIS AG
Patent: WO2008/58961 A1, 2008 ;
Location in patent: Page/Page column 45-46 ;
