N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯合成路线

2488-15-5Boc-L-蛋氨酸+7517-19-3L-亮氨酸甲酯盐酸盐→66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯

参考文献

Freidinger, Roger M.; Perlow, Debra Schwenk; Veber, Daniel F.
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 104 - 109

→66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯

参考文献

Mori, Hiroshi
Patent: EP1498421 A1, 2005 ;

67-56-1甲醇→66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯

参考文献

Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1039 - 1044

2666-93-5(2S)-2-氨基-4-甲基戊酸甲酯+2488-15-5Boc-L-蛋氨酸→66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯

参考文献

Abou Ghalia, M. H.; Salem, Ezzeldin M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 135 - 138

2666-93-5(2S)-2-氨基-4-甲基戊酸甲酯+3845-64-5Boc-Met-Osu→66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯

参考文献

Spisani, Susanna; Turchetti, Marianna; Varani, Katia; Falzarano, Sofia; Cavicchioni, Giorgio
European Journal of Pharmacology, 2003 , vol. 469, # 1-3 p. 13 - 19

687-51-4亮氨酰胺→66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯

参考文献

Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1039 - 1044

33900-24-2→66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯

参考文献

Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1039 - 1044

64-18-6甲酸+66880-59-9N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯→18321-99-8

参考文献

Spisani, Susanna; Turchetti, Marianna; Varani, Katia; Falzarano, Sofia; Cavicchioni, Giorgio
European Journal of Pharmacology, 2003 , vol. 469, # 1-3 p. 13 - 19