1,1,4,4,6-五甲基-1,2,3,4-四氢化萘合成路线 （共 36 条）
反应条件
AlCl3 in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate
参考文献
Reinnervate Limited
Patent: US8293803 B2, 2012 ;
反应条件
1: 85 percent / Br2; AlCl3 / CH2Cl2 2: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 3: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C 4: 88 percent / Pd(OAc)2; P(o-Tol)3; Et3N / dimethylformamide / 2 h / 50 °C View Scheme
参考文献
Zhang; Badea; Enyeart; Berger; Mais; Boehm
Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 7 p. 701 - 712
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / -10 - 44 °C / Inert atmosphere; Reflux 1.2: 15 - 20 °C 2.1: potassium hexamethylsilazane / toluene / 0.75 h / 25 - 50 °C / Inert atmosphere 2.2: 2 h / 0 - 5 °C / Inert atmosphere View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; SARIN, Gurdeep, Singh; SHARMA, Bimal, Kumar; GERA, Pardeep
Patent: WO2011/141928 A1, 2011 ;
反应条件
AlCl3, aluminium chloride in dichloromethane T=20°C; Reflux;
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl, E.; JURUTKA, Peter, W.; MARSHALL, Pamela, A.
Patent: WO2013/40227 A2, 2013 ;
Location in patent: Page/Page column 21; 22 ;
反应条件
1: 85 percent / Br2; AlCl3 / CH2Cl2 2: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 3: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: With AlCl3, aluminium chloride in dichloromethane T=-10 - 44°C; Inert atmosphereReflux; 2: With hydrogenchloride; water in dichloromethane; water T=15 - 20°C;
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; SARIN, Gurdeep, Singh; SHARMA, Bimal, Kumar; GERA, Pardeep
Patent: WO2011/141928 A1, 2011 ;
Location in patent: Page/Page column 18-19 ;
反应条件
1: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C 2: 100 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941
反应条件
AlCl3, aluminium chloride Friedel Crafts Acylation;
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1: With AlCl3, aluminium chloride in dichloromethane T=-10 - 44°C; Inert atmosphereReflux; 2: With hydrogenchloride; water in dichloromethane; water T=15 - 20°C;
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; SARIN, Gurdeep, Singh; SHARMA, Bimal, Kumar; GERA, Pardeep
Patent: WO2011/141928 A1, 2011 ;
Location in patent: Page/Page column 18-19 ;
反应条件
1: AlCl3 / CH2Cl2; nitromethane / 24 h / 15 - 30 °C 2: NaNH2 / tetrahydrofuran View Scheme
参考文献
Boehm; Zhang; Zhi; McClurg; Berger; Wagoner; Mais; Suto; Davies; Heyman; Nadzan
Journal of Medicinal Chemistry, 1995 , vol. 38, # 16 p. 3146 - 3155
