1,1,4,4-四甲基-1,2,3,4-四氢萘合成路线 （共 27 条）
反应条件
sodium hydroxide; nitric acid; acetic acid; palladium monocarbide in ethanol; acetic anhydride
参考文献
Roche Bioscience, a division of Syntex (U.S.A.) LLC
Patent: US2003/125383 A1, 2003 ;
US 20030125383 A1
反应条件
nitric acid; acetic anhydride in acetic acid
参考文献
BASF Aktiengesellschaft
Patent: US5128479 A1, 1992 ;
反应条件
1: 49.9 percent / HNO3, H2SO4 / 1 h / -10 °C 2: 48 percent / hydrogen / Pd/C / ethanol 3: 86.7 percent / pyridine / benzene / Ambient temperature 4: aq. NaOH / ethanol / Ambient temperature View Scheme
参考文献
Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Himi, Toshiyuki; Shudo, Koichi
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2182 - 2192
反应条件
1: 49.9 percent / HNO3, H2SO4 / 1 h / -10 °C 2: 48 percent / hydrogen / Pd/C / ethanol 3: 86.7 percent / pyridine / benzene / Ambient temperature View Scheme
参考文献
Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Himi, Toshiyuki; Shudo, Koichi
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2182 - 2192
反应条件
boron trifluoride diethyl etherate; bromine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Christie, Victoria B.; Barnard, Jonathan H.; Batsanov, Andrei S.; Bridgens, Caroline E.; Cartmell, Emily B.; Collings, Jonathan C.; Maltman, Daniel J.; Redfern, Christopher P. F.; Marder, Todd B.; Przyborski, Stefan; Whiting, Andrew
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 19 p. 3497 - 3507
反应条件
2: aq. KOH / ethanol View Scheme
参考文献
Hoffmann-La Roche
Patent: DE2854354 , 1979 ;
Chem.Abstr., 1979 , vol. 91, # 140631
反应条件
chlorosulfonic acid in dichloromethane T=0°C; 1 h;
参考文献
Research Foundation Itsuu Laboratory
Patent: EP1357104 A1, 2003 ;
Location in patent: Page/Page column 11 ;
反应条件
nitric acid; acetic anhydride T=20°C; 2 h;
参考文献
Fortin, Jessica S.; Cote, Marie-France; Lacroix, Jacques; Desjardins, Michel; Petitclerc, Eric; C.-Gaudreault, Rene
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7277 - 7290
反应条件
nitric acid; acetic anhydride in acetic acid
参考文献
BASF Aktiengesellschaft
Patent: US5128479 A1, 1992 ;
反应条件
AlCl3, aluminium chloride
参考文献
WISCONSIN ALUMNI RESEARCH FOUNDATION
Patent: WO2007/5568 A1, 2007 ;
Location in patent: Page/Page column 10 ;
WO 2007/005568 A1
