4-(3-氟苄氧基)苯甲醛合成路线 （共 11 条）
反应条件
potassium carbonate; sodium iodide in ethanol 5.41667 h; Heating / reflux; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 81 ;
反应条件
potassium carbonate; tetradecyltrimethylammonium bromide in toluene 7 h; Heating / reflux; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 60 ;
反应条件
potassium carbonate; tetradecyltrimethylammonium bromide in toluene 7 h; Heating / reflux; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 60 ;
反应条件
potassium carbonate; potassium iodide in toluene 120 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2009/74478 A1, ;
Page/Page column 73-74 ;
反应条件
1: With triethylamine in methanol T=20 - 25°C; 1 h; 2: With hydrogen; platinum on carbon in methanol T=20 - 35°C; P=750.075 - 3750.38 Torr; 5 h; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 60-62 ;
反应条件
1: in methanol T=20 - 25°C; 1 h; 2: With hydrogen; platinum on carbon in methanol T=20 - 35°C; P=750.075 - 3750.38 Torr; 5 h; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2007/147491 A1, 2007 ;
Location in patent: Page/Page column 32 ;
反应条件
1: With triethylamine in methanol T=25°C; 10.1667 h; 2: With sodium hydroxide; sodium tetrahydroborate in methanol; water T=5 - 10°C; 1 h; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 71-72 ;
反应条件
1: (S)-2-amino-propionamide hydrochloride With sodium methylate in methanol; ethanol T=17 - 23°C; 1.25 h; 2: 4-(3-fluoro-benzyloxy)-benzaldehyde in methanol T=20°C; 20.5 h; 3: With sodium tetrahydroborate in methanol T=3 - 10°C; 2 h; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 64-65 ;
反应条件
1: (2R)-2-amino-propanamide hydrochloride With triethylamine in methanol T=30°C; 0.166667 h; 2: 4-(3-fluoro-benzyloxy)-benzaldehyde in methanol T=30°C; 3.5 h; 3: With sodium hydroxide; sodium tetrahydroborate in methanol; water T=5°C; 2 h; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 66 ;
反应条件
1: With triethylamine in methanol T=25°C; 10.1667 h; 2: With sodium hydroxide; sodium tetrahydroborate in methanol; water T=5 - 10°C; 1 h; Product distribution / selectivity;
参考文献
NEWRON PHARMACEUTICALS S.P.A.
Patent: WO2009/74478 A1, 2009 ;
Location in patent: Page/Page column 71-72 ;
