2-氰基-3-甲基-2-丁烯酸甲酯合成路线 （共 10 条）
反应条件
ammonium acetate; acetic acid in acetone; benzene
参考文献
BASF Aktiengesellschaft
Patent: US6441044 B1, 2002 ;
反应条件
ammonium acetate; acetic acid in acetone; toluene
参考文献
Abbott Laboratories; Abbott GmbH and Co. KG
Patent: US2013/5705 A1, 2013 ;
US 20130005705 A1
反应条件
ammonium acetate; acetic acid in toluene
10 h; Reflux;
参考文献
Tasnadi, Gabor; Winkler, Christoph K.; Clay, Dorina; Sultana, Nargis; Fabian, Walter M. F.; Hall, Melanie; Ditrich, Klaus; Faber, Kurt
Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10362 - 10367
反应条件
acetic acid; calcium chloride in acetone
19 h; Heating;
参考文献
Valla, Alain; Andriamialisoa, Zo; Valla, Benoist; Labia, Roger; Le Guillou, Regis; Dufosse, Laurent; Cartier, Dominique
European Journal of Organic Chemistry, 2007 , # 4 p. 711 - 715
参考文献
Young et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 811
参考文献
Young et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 811
参考文献
Young et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 811
参考文献
Young et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 811
反应条件
piperidine; sulfur in ethanol
T=80°C; Gewald Aminoheterocycles Synthesis;
参考文献
Park, Chun-Ho; Lee, Chulho; Yang, Jee Sun; Joe, Bo-Young; Chun, Kwangwoo; Kim, Hyuntae; Kim, Hye Yun; Kang, Jong Soon; Lee, Jangik I.; Kim, Myung-Hwa; Han, Gyoonhee
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2655 - 2660
反应条件
1.1: MeOK / 48 h / 20 °C
2.1: piperidine / 4 h / Heating
2.2: DIBAL-H / toluene / 2 h
3.1: 85 percent / LiAlH4; TiCl3 / tetrahydrofuran
View Scheme
参考文献
Valla, Alain; Andriamialisoa, Zo; Valla, Benoist; Labia, Roger; Le Guillou, Regis; Dufosse, Laurent; Cartier, Dominique
European Journal of Organic Chemistry, 2007 , # 4 p. 711 - 715
