3-(二甲氨基)-1-(2-吡啶基)-2-丙烯-1-酮合成路线 （共 22 条）
反应条件
1: 1) t-BuOK / 1) THF, 2 h, r.t. 2) 14 h, r.t. 2: NH4OAc, AcOH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 18 p. 1999 - 2002
反应条件
1: potassium tert-butylate / tetrahydrofuran / 1 h 2: acetic acid; potassium carbonate / tetrahydrofuran View Scheme
参考文献
Dalton Transactions, , vol. 42, # 22 p. 8086 - 8103
反应条件
1: 2-acetyl-thiophene With potassium tert-butylate in tetrahydrofuran T=20°C; 2 h; 2: 2-[3-(N,N-dimethylamino)-1-oxoprop-2-en-1-yl]pyridine in tetrahydrofuran 14 h; 3: With ammonium acetate; acetic acid in tetrahydrofuran 2 h; Reflux;
参考文献
Bozic-Weber, Biljana; Constable, Edwin C.; Housecroft, Catherine E.; Kopecky, Peter; Neuburger, Markus; Zampese, Jennifer A.
Dalton Transactions, 2011 , vol. 40, # 46 p. 12584 - 12594
反应条件
1: ethanol / 85 °C 2: sodium hydride / tetrahydrofuran / 65 °C View Scheme
参考文献
Yu, Xian-Yong; Deng, Lin; Zheng, Baishu; Zeng, Bi-Rong; Yi, Pinggui; Xu, Xin
Dalton Transactions, 2014 , vol. 43, # 4 p. 1524 - 1533
反应条件
in V methoxymethyl ester 6 h; Inert atmosphereReflux;
参考文献
Comes Franchini, Mauro; Bonini, Bianca Flavia; Camaggi, Carlo Maurizio; Gentili, Denis; Pession, Annalisa; Rani, Monica; Strocchi, Elena
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2024 - 2033
反应条件
1: 2-acetyl-thiophene With potassium tert-butylate in tetrahydrofuran T=20°C; 2 h; 2: 2-[3-(N,N-dimethylamino)-1-oxoprop-2-en-1-yl]pyridine in tetrahydrofuran 14 h; 3: With ammonium acetate; acetic acid in tetrahydrofuran 2 h; Reflux;
参考文献
Bozic-Weber, Biljana; Constable, Edwin C.; Housecroft, Catherine E.; Kopecky, Peter; Neuburger, Markus; Zampese, Jennifer A.
Dalton Transactions, 2011 , vol. 40, # 46 p. 12584 - 12594
反应条件
1: ethanol / 85 °C
2: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 80 °C
View Scheme
参考文献
Yu, Xian-Yong; Deng, Lin; Zheng, Baishu; Zeng, Bi-Rong; Yi, Pinggui; Xu, Xin
Dalton Transactions, 2014 , vol. 43, # 4 p. 1524 - 1533
反应条件
in V methoxymethyl ester
6 h; Inert atmosphereReflux;
参考文献
Comes Franchini, Mauro; Bonini, Bianca Flavia; Camaggi, Carlo Maurizio; Gentili, Denis; Pession, Annalisa; Rani, Monica; Strocchi, Elena
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2024 - 2033
反应条件
1: hydroxylamine hydrochloride / 3 h / Heating
2: 18 h / Heating
3: hydrazine hydrate
View Scheme
参考文献
Powell, Dennis; Gopalsamy, Ariamala; Wang, Yanong D.; Zhang, Nan; Miranda, Miriam; McGinnis, John P.; Rabindran, Sridhar K.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1641 - 1645
反应条件
1: sodium hydroxide / butan-1-ol / 12 h / |Inert atmosphere; |Schlenk technique; |Reflux
2: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / 1,4-dioxane / 20 h / 20 - 100 °C / |Inert atmosphere; |Schlenk technique
3: hydrazine hydrate; anhydrous iron chloride; carbon / water / 80 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
