3-氯甲基-1-甲基哌啶 盐酸盐合成路线 (共 2 条)
反应条件
hydrogenchloride; thionyl chloride in chloroform 1.5 h; Heating;
参考文献
Balsamo, A.; Lapucci, A.; Lucacchini A.; Macchia, M.; Martini, C.; et al.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 12 p. 967 - 974
反应条件
1: 2-chloro-phenothiazine With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C; 0.366667 h;
2: 3-chloromethyl-1-methylpiperidine hydrochloride in N,N-dimethyl-formamide; mineral oil
T=65°C; 16 h;
参考文献
HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH); KRAPPMANN, Daniel; NAGEL, Daniel; SCHLAUDERER, Florian; LAMMENS, Katja; HOPFNER, Karl-Peter; CHRUSCIEL, Robert, A.; KLING, Dale, L.; BEDORE, Matthew, W.
Patent: WO2014/86478 A1, 2014 ;
Location in patent: Page/Page column 86 ;