7-氨基-3,4-二氢异喹啉-1(2H)-酮合成路线 （共 19 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: HNO3; H2SO4 / 0 °C 2: H2 / Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3394 - 3405
反应条件
1: 94 percent / KOH, H2O2 / H2O; methanol / 0.5 h / Ambient temperature 2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C 3: 93 percent / H2 / 10percent Pd/C / methanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 57 percent / PPA / 0.25 h / 145 °C 2: 94 percent / KOH, H2O2 / H2O; methanol / 0.5 h / Ambient temperature 3: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C 4: 93 percent / H2 / 10percent Pd/C / methanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 19 p. 3220 - 3234
反应条件
1: PhIO; NaOH 2: HNO3; H2SO4 / 0 °C 3: H2 / Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3394 - 3405
反应条件
1: 86 percent / conc. HCl / methanol / 0.08 h / Heating 2: 93 percent / H2 / 10percent Pd/C / methanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 19 p. 3220 - 3234
反应条件
1.1: polyphosphoric acid / 6 h / 115 - 120 °C 2.1: potassium nitrate; sulfuric acid / 3 h / 0 - 20 °C 2.2: 20 °C 3.1: hydrogen / palladium 10 on activated carbon / methanol / 3.5 h / 20 °C / Inert atmosphere View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
反应条件
1: sodium carbonate / ethyl acetate; water / 2 h / 0 - 20 °C 2: polyphosphoric acid / 2.5 h / 140 - 160 °C 3: sulfuric acid; nitric acid / 2 h / |Cooling with ice 4: hydrogen; palladium 10 on activated carbon / methanol / 20 °C / 2068.65 Torr View Scheme
反应条件
1: With hydrogen bromide in water; acetonitrile T=0°C; 0.5 h; 2: With sodium nitrite in water; acetonitrile T=0°C; 0.9 h; 3: With copper(I) bromide in water; acetonitrile T=0 - 70°C; 1.66667 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122258 A1, 2007 ;
Location in patent: Page/Page column 76 ;
反应条件
hydrogenchloride; potassium iodide; sodium nitrite 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
