1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl acetamide
T=200°C; 1 h; microwave irradiation;
参考文献
Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A.
Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9645 - 9647
1.1: sodium acetate / acetic acid / 3 h / |Reflux
2.1: sodium hydroxide; water / 1.5 h / 20 °C
2.2: 0.5 h / 10 °C / |Cooling with ice
3.1: potassium hydroxide / water / 4 h / |Reflux
3.2: 1 h / 20 °C / pH 1
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 160 - 195 °C
View Scheme
1.1: sodium hydroxide; water / 1.5 h / 20 °C
1.2: 0.5 h / 10 °C / |Cooling with ice
2.1: potassium hydroxide / water / 4 h / |Reflux
2.2: 1 h / 20 °C / pH 1
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 160 - 195 °C
View Scheme
