反应条件
1: palladium diacetate; triphenylphosphine; diisopropylamine; copper(l) iodide / N,N-dimethyl-formamide / 1.25 h / 40 - 60 °C / |Inert atmosphere
2: potassium carbonate / methanol / 2.5 h / 20 °C
View Scheme
参考文献
Naud, Sebastien; Westwood, Isaac M.; Faisal, Amir; Sheldrake, Peter; Bavetsias, Vassilios; Atrash, Butrus; Cheung, Kwai-Ming J.; Liu, Manjuan; Hayes, Angela; Schmitt, Jessica; Wood, Amy; Choi, Vanessa; Boxall, Kathy; Mak, Grace; Gurden, Mark; Valenti, Melanie; De Haven Brandon, Alexis; Henley, Alan; Baker, Ross; McAndrew, Craig; Matijssen, Berry; Burke, Rosemary; Hoelder, Swen; Eccles, Suzanne A.; Raynaud, Florence I.; Linardopoulos, Spiros; Van Montfort, Rob L. M.; Blagg, Julian
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10045 - 10065