(6-溴-1,3-苯并二氧代l-5-基)甲醇合成路线 （共 37 条）
反应条件
1: formamide With copper (I) cyanide in water
T=100°C;
2: 4-bromo-5-hydroxymethyl-1,2-methylenedioxybenzene in water
T=100 - 178°C;
参考文献
Attaluri, Sivaprasad; Bonala, Radha R.; Yang, In-Young; Lukin, Mark A.; Wen, Yujing; Grollman, Arthur P.; Moriya, Masaaki; Iden, Charles R.; Johnson, Francis
Nucleic Acids Research, 2010 , vol. 38, # 1 art. no. GKP815, p. 339 - 352
反应条件
1: benzene; hydrogen chloride
2: ethanol
3: aq.-ethanolic NaOH-solution
View Scheme
参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
反应条件
1: PCC / CH2Cl2
2: CrO3; H2SO4 / acetone
View Scheme
参考文献
Bressy, Cyril; Menant, Christine; Piva, Olivier
Synlett, 2005 , # 4 art. no. D35104ST, p. 577 - 582
反应条件
hydrogenchloride; benzene
参考文献
Wada, Yasuhiro; Kaga, Harumi; Uchiito, Shiho; Kumazawa, Eri; Tomiki, Miho; Onozaki, Yu; Kurono, Nobuhito; Tokuda, Masao; Ohkuma, Takeshi; Orito, Kazuhiko
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7301 - 7306
反应条件
phosphorus tribromide in diethyl ether; benzene
1 h; Heating;
参考文献
Mervic, Miljenko; Ghera, Eugene
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4720 - 4725
反应条件
1: benzene; hydrogen chloride
2: ethanol
View Scheme
参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
反应条件
1.1: phosphorus tribromide / diethyl ether / 0.83 h / 0 - 23 °C / |Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / |Inert atmosphere
2.2: 0 - 23 °C / |Inert atmosphere
3.1: hydrazine hydrate / 3 h / 120 °C / |Inert atmosphere
4.1: N,N-dimethylethylenediamine; potassium tert-butylate / 1,3,5-trimethyl-benzene / 6 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
De, Subhadip; Ghosh, Santanu; Bhunia, Subhajit; Sheikh, Javeed Ahmad; Bisai, Alakesh
Organic Letters, 2012 , vol. 14, # 17 p. 4466 - 4469
