Alpha-甲基乙酰丙酸合成路线 （共 36 条）
反应条件
hydrazine hydrate in ethanol
2 h; Heating;
参考文献
Hu, Wenhui; Ralay Ranaivo, Hantamalala; Roy, Saktimayee M.; Behanna, Heather A.; Wing, Laura K.; Munoz, Lenka; Guo, Ling; Van Eldik, Linda J.; Watterson, D. Martin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 414 - 418
反应条件
potassium hydroxide; hydrazine hydrate in diethylene glycol
Heating;
参考文献
Scarpati,R. et al.
Gazzetta Chimica Italiana, 1967 , vol. 97, p. 654 - 664
反应条件
1: 89 percent / H3PO4 / 4 h / 140 - 150 °C
2: Br2 / CS2
3: DBU / benzene / 5 h / -20 - 20 °C
4: 88 percent / NH4Cl / electrochemical halogenation
5: 86 percent / aq. HCl / dioxane / 6 h / Heating
View Scheme
参考文献
Torii; Inokuchi; Kondo
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 7 p. 2183 - 2184
反应条件
phosphoric acid
T=140 - 150°C; 4 h;
参考文献
Han, Yongbin; Hou, Shuyu; Simon, Karen A.; Ren, Dacheng; Luk, Yan-Yeung
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1006 - 1010
反应条件
1: phosphorus (V)-sulfide
2: benzene; water containing phosphoric acid
View Scheme
参考文献
Hartough
Journal of the American Chemical Society, 1951 , vol. 73, p. 4033
反应条件
1: 89 percent / H3PO4 / 4 h / 140 - 150 °C
2: Br2 / CS2
3: DBU / benzene / 5 h / -20 - 20 °C
View Scheme
参考文献
Torii; Inokuchi; Kondo
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 7 p. 2183 - 2184
