Alpha-甲基乙酰丙酸合成路线 （共 36 条）
反应条件
potassium hydroxide; hydrazine hydrate in diethylene glycol Heating;
参考文献
Scarpati,R. et al.
Gazzetta Chimica Italiana, 1967 , vol. 97, p. 654 - 664
反应条件
diphosphorus trisulfide
参考文献
Hartough
Journal of the American Chemical Society, 1951 , vol. 73, p. 4033
参考文献
Bischoff
Justus Liebigs Annalen der Chemie, 1881 , vol. 206, p. 319
Justus Liebigs Annalen der Chemie, 1882 , vol. 214, p. 55
反应条件
1: 98.7 percent / hydrazine monohydrate / ethanol / 2 h / Heating 2: acetic acid; bromine / 1.5 h / 70 °C 3: POCl3 / acetonitrile / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 2 p. 414 - 418
反应条件
tert-butyl peroxyacetate
T=95°C; 16 h;
参考文献
Jaouhari, Rabih; Filliatre, Claude; Villenave, Jean-Jacques
Canadian Journal of Chemistry, 1983 , vol. 61, p. 2295 - 2298
反应条件
oxygen; ozone in dichloromethane
T=-78°C; 0.75 h;
参考文献
Yates, Peter; Burke, Patrick Michael
Canadian Journal of Chemistry, 1987 , vol. 65, p. 1695 - 1704
反应条件
1: Ba(OH)2 / Verseifung
2: Destillation
View Scheme
参考文献
Michael; Ross
Journal of the American Chemical Society, 1931 , vol. 53, p. 2407
Journal of the American Chemical Society, 1932 , vol. 54, p. 388
反应条件
dihydrogen peroxide; potassium carbonate in methanol; water
T=0 - 20°C; Nef reaction;
参考文献
Aginagalde, Maialen; Bello, Tamara; Masdeu, Carme; Vara, Yosu; Arrieta, Ana; Cossio, Fernando P.
Journal of Organic Chemistry, 2010 , vol. 75, # 21 p. 7435 - 7438
反应条件
tetrabutylammonium halide in N,N-dimethyl-formamide
Ambient temperatureelectrolysis, Mg anode;
参考文献
Mcharek, Slah; Heintz, Monique; Troupel, Michel; Perichon, Jacques
Bulletin de la Societe Chimique de France, 1989 , # 1 p. 95 - 97
反应条件
1: 50percent H2SO4 / 2 h / 50 °C
2: 8.4 percent Chromat. / 99.5percent H2SO4 / 1.) 5 deg C, 24 h; 2.) r.t., 168 h
3: 0.59 g / O3/O2 / CH2Cl2 / 0.75 h / -78 °C
View Scheme
参考文献
Yates, Peter; Burke, Patrick Michael
Canadian Journal of Chemistry, 1987 , vol. 65, p. 1695 - 1704
