4,5-二氯-2-硝基苯胺合成路线 （共 26 条）
反应条件
4-(N,N-dimethlyamino)pyridine in toluene
参考文献
Nisshin Flour Milling Co., Ltd.
Patent: US5576335 A1, 1996 ;
反应条件
potassium carbonate in water; N,N-dimethyl-formamide T=125°C; 3 h;
参考文献
Hernandez-Luis, Francisco; Hernandez-Campos, Alicia; Castillo, Rafael; Navarrete-Vazquez, Gabriel; Soria-Arteche, Olivia; Hernandez-Hernandez, Manuel; Yepez-Mulia, Lilian
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 3135 - 3141
反应条件
1: 1.) aq. HCl, 2.) NaN3 / 1.) 0 deg C, 10 min, 2.) H2O, 0 deg C, 15 min 2: 92 percent / toluene / 4 h / Heating 3: 30 percent / NH3 gas / methanol / Ambient temperature View Scheme
参考文献
Monge; Palop; Gonzalez; Martinez-Crespo; Lopez De Cerain; Sainz; Narro; Barker; Hamilton
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 4 p. 1213 - 1217
反应条件
hydrogenchloride; palladium monocarbide in ethanol
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
1: 1.) t-BuONO, BF3*Et2O, 2.) CuCN / 1.) THF, CH2Cl2, -10 deg C, 2.) H2O, rt, overnight
2: 83.6 percent / BH3*THF / tetrahydrofuran / Ambient temperature
3: 1.) NaNO2, AcOH, 2.) NaOH / 1.) H2O, 0 deg C, 10 min, rt, 15 min, 2.) MeOH, H2O, rt, 10 min
4: 80 percent / PCC / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Zhu, Zhijian; Lippa, Blaise; Townsend, Leroy B.
Journal of Organic Chemistry, 1999 , vol. 64, # 11 p. 4159 - 4168
反应条件
1: arsenic acid; concentrated sulfuric acid
2: SnCl2+2 H2O; ethanol
View Scheme
参考文献
Case et al.
Journal of Organic Chemistry, 1954 , vol. 19, p. 31,34, 35
