1: cyclobenzothiazole With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C; 2 h; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III
Patent: WO2012/178015 A2, 2012 ;
Location in patent: Page/Page column 114 ;
WO 2012/178015 A2
1: With diisobutylaluminium hydride in hexanes; dichloromethane T=-50°C; 2: With hydrogenchloride; water in hexanes; dichloromethane; ethyl acetate T=20°C;
参考文献
MEDIVIR AB
Patent: WO2008/107365 A1, 2008 ;
Location in patent: Page/Page column 82 ;
WO 2008/107365 A1
