1: (4-chlorophenoxy)-acetic acid With 1,1'-carbonyldiimidazole in dichloromethane T=0 - 23°C; 2: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane T=0 - 10°C;
参考文献
Beutner, Gregory L.; Kuethe, Jeffrey T.; Kim, Mary M.; Yasuda, Nobuyoshi
Journal of Organic Chemistry, 2009 , vol. 74, # 2 p. 789 - 794
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in DMF (N,N-dimethyl-formamide) 63 h; 2: With sodium hydroxide in water
参考文献
Eli Lilly and Company
Patent: US6777428 B1, 2004 ;
Location in patent: Page column 24-25 ;
US 6777428 B1
1: 3{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 0.5 h; 2: O,N-dimethyl-hydroxylamine hydrochloride With 1H-imidazole in tetrahydrofuran T=20°C; 5 h;
1H-imidazole in tetrahydrofuran 4 h; Ambient temperature;
参考文献
Wu, Chengde; Chan, Ming F.; Stavros, Fiona; Raju; Okun, Ilya; Mong, Seymour; Keller, Karin M.; Brock, Tommy; Kogan, Timothy P.; Dixon, Richard A. F.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1690 - 1697
