2-(2-碘苯基)乙酸甲酯合成路线 （共 19 条）
反应条件
1.1: (COCl)2; DMF / tetrahydrofuran; benzene / 0.5 h / 0 °C
1.2: 79 percent / diethyl ether; tetrahydrofuran / 2 h / 0 °C
2.1: 86 percent / AgOBz; NEt3 / 0.5 h / 20 °C
View Scheme
参考文献
Deville, Jay P; Behar, Victor
Organic letters, 2002 , vol. 4, # 8 p. 1403 - 1405
反应条件
1: aq. NaOH / ethanol / 6.5 h / Heating
2: H2SO4 / 2.5 h / Heating
View Scheme
参考文献
Reboredo, Francisco J.; Treus, Monica; Estevez, Juan C.; Castedo, Luis; Estevez, Ramon J.
Synlett, 2003 , # 11 p. 1603 - 1606
反应条件
1: dimethylsulfoxide / 14 h / 70 °C
2: aq. NaOH / ethanol / 6.5 h / Heating
3: H2SO4 / 2.5 h / Heating
View Scheme
参考文献
Reboredo, Francisco J.; Treus, Monica; Estevez, Juan C.; Castedo, Luis; Estevez, Ramon J.
Synlett, 2003 , # 11 p. 1603 - 1606
反应条件
1: diethyl ether
2: Hg2O
View Scheme
参考文献
Kobayashi; Uyeo
Journal of the Chemical Society, 1957 , p. 638,640
反应条件
1: 98 percent / PdCl2(PPh3)2; CuI; diisopropylamine / dioxane / 8 h / 20 °C
2: 87 percent / aq. KF; 18-crown-6 / dioxane / 1 h / 20 °C
3: 49 percent / TfOH; (PPh3)AuCH3; H2O / methanol / 18 h / 70 °C
4: 77 percent / N-methylimidazole / methanol / Irradiation
View Scheme
参考文献
Wessig, Pablo; Glombitza, Clemens; Mueller, Gunnar; Teubner, Janek
Journal of Organic Chemistry, 2004 , vol. 69, # 22 p. 7582 - 7591
反应条件
1: triethyl orthopropiolate; 2-iodophenylacetic acid methyl ester With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in acetonitrile
T=0 - 20°C; Sonogashira coupling; 3.5 h;
2: methanol With toluene-4-sulfonic acid in benzene
T=20°C; 12 h; Further stages.;
参考文献
Deville, Jay P; Behar, Victor
Organic letters, 2002 , vol. 4, # 8 p. 1403 - 1405
反应条件
1: aq. NaOH
2: SOCl2
View Scheme
参考文献
Leffler,J.E.; Wilson,A.F.
Journal of Organic Chemistry, 1960 , vol. 25, p. 424 - 428
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide
2: With potassium fluoride; 18-crown-6 ether
参考文献
Mei, Tian-Sheng; Wang, Dong-Hui; Yu, Jin-Quan
Organic Letters, 2010 , vol. 12, # 14 p. 3140 - 3143
反应条件
1: 90 percent / PPh3; triethylamine / CuI; PdCl2(PPh3)2 / tetrahydrofuran / 12 h / 20 °C
2: 88 percent / potasssium carbonate / methanol; ethanol
View Scheme
参考文献
Marchal, Estelle; Uriac, Philippe; Legouin, Beatrice; Toupet, Loic; Weghe, Pierre van de
Tetrahedron, 2007 , vol. 63, # 40 p. 9979 - 9990
