反应条件
1: aq. NaHCO3 / 15 h / 90 °C
2: aq. NaHCO3; I2 / 48 h / 20 °C
3: 11.4 g / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 3 h / 20 °C
4: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C
5: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating
6: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Wishka, Donn G.; Walker, Daniel P.; Yates, Karen M.; Reitz, Steven C.; Jia, Shaojuan; Myers, Jason K.; Olson, Kirk L.; Jacobsen, E. Jon; Wolfe, Mark L.; Groppi, Vincent E.; Hanchar, Alexander J.; Thornburgh, Bruce A.; Cortes-Burgos, Luz A.; Wong, Erik H. F.; Staton, Brian A.; Raub, Thomas J.; Higdon, Nicole R.; Wall, Theron M.; Hurst, Raymond S.; Walters, Rodney R.; Hoffmann, William E.; Hajos, Mihaly; Franklin, Stanley; Carey, Galen; Gold, Lisa H.; Cook, Karen K.; Sands, Steven B.; Zhao, Sabrina X.; Soglia, John R.; Kalgutkar, Amit S.; Arneric, Stephen P.; Rogers, Bruce N.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4425 - 4436