6-氯-2-吡啶羧酸甲酯合成路线 （共 15 条）
反应条件
thionyl chloride T=0 - 50°C; 6.75 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26871 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/026871 A1
反应条件
trichlorophosphate T=110°C; 14 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/120098 A1, 2007 ;
Location in patent: Page/Page column 73-74 ;
WO 2007/120098 A1
反应条件
triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride T=140°C; methoxycarbonylation; P=37503 Torr; 6 h;
参考文献
Najiba, Douja; Carpentier, Jean-Francois; Castanet, Yves; Biot, Christophe; Brocard, Jacques; Mortreux, Andre
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3719 - 3722
反应条件
in dichloromethane T=20°C; 1.58333 h;
参考文献
WO2012/49277 A1, ;
Page/Page column 37 ;
WO 2012/049277 A1
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1287
反应条件
18-crown-6 ether; potassium carbonate T=90 - 150°C; 2 h;
参考文献
Renga, James M.; Wang, Pen-Chung
Synthetic Communications, 1984 , vol. 14, # 1 p. 77 - 82
反应条件
1: 2-Pyridinecarboxylic acid methyl ester With fluorine in dichloromethane T=-78 - -50°C; 2: p-isocyanonitrobenzene in dichloromethane T=-50 - 0°C; 4 h;
参考文献
Tetrahedron Letters, , vol. 46, # 13 p. 2279 - 2282
反应条件
1: mCPBA / CH2Cl2 / 48 h / Ambient temperature 2: POCl3 / 17 h / 80 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 6 p. 455 - 460
反应条件
trichlorophosphate T=80°C; 17 h; Yield given. Yields of byproduct given;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 6 p. 455 - 460
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 3 p. 206 - 210
