2-甲氧基-4-甲基-5-硝基吡啶合成路线 （共 11 条）
反应条件
in methanol T=0 - 20°C;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/186879 A1, 2009 ;
Location in patent: Page/Page column 59 ;
US 20090186879 A1
反应条件
sodium T=0 - 20°C; 2 h;
参考文献
Phenex Pharmaceuticals AG
Patent: EP1894924 A1, 2008 ;
Location in patent: Page/Page column 33 ;
反应条件
sodium methylate in methanol; water
反应条件
1: concentrated H2SO4; concentrated HNO3 2: aqueous sulfuric acid; sodium nitrite / Diazotization 3: phosphorus (V)-chloride; phosphoryl chloride 4: methanol View Scheme
参考文献
Journal of the Chemical Society, , p. 2448,2455
反应条件
1: phosphorus (V)-chloride; phosphoryl chloride 2: methanol View Scheme
参考文献
Journal of the Chemical Society, , p. 2448,2455
反应条件
1: aqueous sulfuric acid; sodium nitrite / Diazotization 2: phosphorus (V)-chloride; phosphoryl chloride 3: methanol View Scheme
参考文献
Journal of the Chemical Society, , p. 2448,2455
反应条件
1.1: potassium tert-butylate / diethyl ether; ethanol / 0.25 h 1.2: Reflux 1.3: 2 h / 20 °C 2.1: hydrogen / palladium on carbon / ethanol / 24 h View Scheme
参考文献
LES LABORATOIRES SERVIER
Patent: US2011/112104 A1, 2011 ;
反应条件
hydrogen bromide in acetic acid T=0 - 60°C; 2 h;
参考文献
Phenex Pharmaceuticals AG
Patent: EP1894924 A1, 2008 ;
Location in patent: Page/Page column 33 ;
反应条件
ethanol; iron; acetic acid
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/186879 A1, 2009 ;
Location in patent: Page/Page column 59 ;
US 20090186879 A1
反应条件
hydrogenchloride in acetic acid
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US5366972 A1, 1994 ;
