反应条件
1: 5-nitro-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid With thionyl chloride; N,N-dimethyl-formamide 8 h; Reflux; 2: methanol in dichloromethane T=-40 - -30°C; 3: With sodium hydrogencarbonate in dichloromethane; water T=-30 - 20°C;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; OALMANN, Christopher; DISCH, Jeremy, S.; NG, Pui, Yee; PERNI, Robert, B.
Patent: WO2010/71853 A1, 2010 ;
Location in patent: Page/Page column 68 ;