3’-叠氮-2’,3’-双脱氧腺苷合成路线 （共 12 条）
反应条件
lithium azide in N,N-dimethyl-formamide T=80°C; 4 h;
参考文献
Herdewijn; Pauwels; Baba; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2131 - 2137
参考文献
Herdewijn; Balzarini; Baba; Pauwels; Van Aerschot; Janssen; De Clerq
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2040 - 2048
反应条件
1: 1.) trifluoromethanesulfonic anhydride, pyridine, 2.) H2O / 1.) CH2Cl2, 30 min, 2.) RT, 3 h 2: ammonia / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 21 p. 5050 - 5053
反应条件
1: 77 percent / pyridine; dimethylformamide / 4 °C 2: 68 percent / LiN3, Ph3P / dimethylformamide; various solvent(s) / 24 h / Ambient temperature 3: 88 percent / NH3 / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 10 p. 2040 - 2048
反应条件
1: 68 percent / LiN3, Ph3P / dimethylformamide; various solvent(s) / 24 h / Ambient temperature 2: 88 percent / NH3 / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 10 p. 2040 - 2048
反应条件
1: p-toluenesulfonic acid / CH2Cl2; methanol / 0.58 h / Ambient temperature 2: 90 percent / LiN3 / dimethylformamide / 4 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 2131 - 2137
反应条件
1: pyridine / 0 °C 2: p-toluenesulfonic acid / CH2Cl2; methanol / 0.58 h / Ambient temperature 3: 90 percent / LiN3 / dimethylformamide / 4 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 2131 - 2137
反应条件
ammonia in methanol Ambient temperature; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 53, # 21 p. 5050 - 5053
反应条件
1: 78 percent / Na2CO3 / methanol / 1.5 h / Ambient temperature 2: ammonia / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 21 p. 5050 - 5053
反应条件
1: N,O-bis-trimethylsilylacetamide / acetonitrile / 0.25 h / Heating 2: 17.3 mg / trimethylsilyl trifluoromethanesulphonate / 2 h / Heating View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 3 p. 462 - 470
