1-苯氧基-3-(4-苯基哌嗪基)丙烷合成路线 （共 7 条）
反应条件
lithium carbonate in acetonitrile
24 h; RefluxInert atmosphere;
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
sodium carbonate; potassium iodide in butan-1-ol
18 h; Heating;
参考文献
Walsh, David A.; Chen, Ying-Ho; Green, Jerry B.; Nolan, Joseph C.; Yanni, John M.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1823 - 1827
反应条件
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
1.1: potassium carbonate / acetone / 27 h / 20 °C
2.1: dimethylsulfide borane complex / dichloromethane / 5 h / 20 °C / Darkness; Inert atmosphere
2.2: 20 h / 20 °C
3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
4.1: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
1: 55 percent / 25percent KOH / acetone / 8 h
2: NaOH / ethanol; H2O / Heating
View Scheme
参考文献
Agarwal, Shiv K.; Kumar, Yatendra; Saxena, Anil K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 435 - 439
反应条件
1.1: dimethylsulfide borane complex / dichloromethane / 5 h / 20 °C / Darkness; Inert atmosphere
1.2: 20 h / 20 °C
2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3.1: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
sodium hydroxide in ethanol; water
Heating; Yield given;
参考文献
Agarwal, Shiv K.; Kumar, Yatendra; Saxena, Anil K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 435 - 439
