4-氨基-4'-溴二苯基砜合成路线 （共 9 条）
反应条件
ammonia; water; copper T=210 - 220°C;
参考文献
Amstutz; Neumoyer
Journal of the American Chemical Society, 1947 , vol. 69, p. 1925,1928
反应条件
1: With hydrogenchloride; SnCl2·2H2O; acetic acid in methanol
T=80°C;
2: With sodium hydroxide in water
参考文献
4SC AG
Patent: US2010/197640 A1, 2010 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: aqueous H2O2; glacial acetic acid
2: tin (II)-chloride; hydrogen chloride; acetic acid / 80 - 85 °C
View Scheme
参考文献
Amstutz; Neumoyer
Journal of the American Chemical Society, 1947 , vol. 69, p. 1925,1928
反应条件
1: KHCO3; ethanol
2: aqueous H2O2; glacial acetic acid
3: tin (II)-chloride; hydrogen chloride; acetic acid / 80 - 85 °C
View Scheme
参考文献
Amstutz; Neumoyer
Journal of the American Chemical Society, 1947 , vol. 69, p. 1925,1928
反应条件
1: KHCO3; ethanol
2: aqueous H2O2; glacial acetic acid
3: tin (II)-chloride; hydrogen chloride; acetic acid / 80 - 85 °C
View Scheme
参考文献
Amstutz; Neumoyer
Journal of the American Chemical Society, 1947 , vol. 69, p. 1925,1928
反应条件
1: zinc-powder; aqueous H2SO4 / -5 - 0 °C
2: KHCO3; ethanol
3: aqueous H2O2; glacial acetic acid
4: tin (II)-chloride; hydrogen chloride; acetic acid / 80 - 85 °C
View Scheme
参考文献
Amstutz; Neumoyer
Journal of the American Chemical Society, 1947 , vol. 69, p. 1925,1928
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C
1.2: 16 h / 80 °C
2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 20 °C / Cooling with ice
3.1: SnCl2·2H2O / ethanol / 2 h / 70 °C
3.2: 1 h
View Scheme
参考文献
FORMA THERAPEUTICS, INC.; GENENTECH, INC.; BAIR, Kenneth W.; BAUMEISTER, Timm B.; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; HAN, Bingsong; LIN, Jian; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZHENG, Xiaozhang; YUEN, Po-Wai
Patent: WO2012/31196 A1, 2012 ;
WO 2012/031196 A1
参考文献
Mavrodin et al.
Pharmazeutische Zentralhalle, 1956 , vol. 95, p. 353,359
反应条件
1: aqueous H2SO4 / Diazotization.Kochen der Diazoniumsalz-Loesung mit einer wss. Loesung von CuSO4 und NaBr
2: sodium dithionite; aqueous ethanol
View Scheme
参考文献
Ganapathi; Venkataraman
Proceedings - Indian Academy of Sciences, Section A, 1945 , # 21 p. 34,39
