2,2,2-三甲基乙酰苯胺合成路线 （共 72 条）
反应条件
in acetonitrile 2 h; Ambient temperature; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 46, p. 4413 - 4416
参考文献
Chemische Berichte, , vol. 44, p. 1202
反应条件
copper(l) chloride in tert-butyl alcohol T=30°C; 24 h; Inert atmosphereSealed tube; Catalytic behavior; SolventTemperatureTime; regioselective reaction;
参考文献
Cai, Shangjun; Chen, Chao; Sun, Zelin; Xi, Chanjuan
Chemical Communications, 2013 , vol. 49, # 40 p. 4552 - 4554
反应条件
2: 1.) a.) concd. sulfuric acid, sodium nitrite, b.) urea / 1.) a.) water, from 0 to 5 deg C, 2.) 30 deg C, irradiation, 2 h View Scheme
参考文献
Kyba, Evan P.; Liu, Shiuh-Tzung; Chockalingam, Kannappan; Reddy, B. Raghava
Journal of Organic Chemistry, 1988 , vol. 53, # 15 p. 3513 - 3521
反应条件
1: 59 percent / n-BuLi / tetrahydrofuran / 6 h / 0 °C 2: 79 percent / 12N HCl / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Hewawasam, Piyasena; Meanwell, Nicholas A.
Tetrahedron Letters, 1994 , vol. 35, # 40 p. 7303 - 7306
反应条件
1.1: n-BuLi 1.2: 58 percent / B(OMe)3 2.1: 42 percent / tetrakis(triphenylphosphine)-palladium(0); aq. potassium carbonate / ethanol; 1,2-dimethoxy-ethane / 24 h / Heating View Scheme
参考文献
Audoux, Jerome; Achelle, Sylvain; Turck, Alain; Marsais, Francis; Ple, Nelly
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1497 - 1503
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C 1.2: -78 - 20 °C 1.3: -78 - 20 °C 2.1: hydrogenchloride; water / 1,4-dioxane / 6 h / Reflux View Scheme
参考文献
Cui, Jian-Fang; Huang, Hui; Wong, Henry N. C.
Synlett, 2011 , # 7 p. 1018 - 1022
反应条件
1.1: n-BuLi / tetrahydrofuran; diethyl ether; hexane / 20 h / 25 °C 1.2: 62 percent / tetrahydrofuran; diethyl ether; hexane / 4 h / 20 °C 2.1: 86 percent / Pd(OAc)2; PPh3; TBAF / dimethylformamide; tetrahydrofuran / 90 °C View Scheme
参考文献
Seganish, W. Michael; DeShong, Philip
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6790 - 6795
反应条件
1: With n-butyllithium 2: With boric acid trimethyl ester
参考文献
Audoux, Jerome; Achelle, Sylvain; Turck, Alain; Marsais, Francis; Ple, Nelly
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1497 - 1503
反应条件
1: With Bu4MgLi2 in tetrahydrofuran; hexane RefluxInert atmosphere; 2: With iodine in tetrahydrofuran; hexane 2 h; Inert atmosphereReflux;
参考文献
Chemical Communications, , vol. 46, # 37 p. 7043 - 7045
