2,2,2-三甲基乙酰苯胺合成路线 （共 72 条）
反应条件
1: 90 percent / aq. Na2CO3 / H2O; CH2Cl2 / 3 h 2: 1.)MeLi/ether, t-BuLi / 1.) THF, pentane, -78 deg C, 1 h; 2.) -10 deg C, 30 min, then ambient temp., 30 min View Scheme
参考文献
Tetrahedron, , vol. 39, # 22 p. 3767 - 3776
反应条件
1: CF3COOH / CH2Cl2 / 0.25 h / 20 °C 2: 99 percent / Et3N / benzene / 0.25 h View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 10 p. 1271 - 1279
反应条件
1.1: water / 4.17 h / 275 °C / |Inert atmosphere; |Green chemistry 2.1: triethylamine / dichloromethane / 0.17 h / |Inert atmosphere; |Cooling with ice 2.2: 25 °C / |Inert atmosphere; |Cooling with ice View Scheme
参考文献
Green Chemistry, , vol. 16, # 4 p. 2147 - 2155
反应条件
in acetonitrile T=60°C; 2 h; Yield given;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 35, # 10 p. 4294 - 4301
反应条件
TEA in various solvent(s) 2 h; Ambient temperature; Yield given;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 6 p. 1636 - 1641
反应条件
1: diethyl ether / Ambient temperature 2: water / diethyl ether View Scheme
参考文献
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, , vol. 40, # 8 p. 1077 - 1086
反应条件
1: diethyl ether / Ambient temperature 2: water / diethyl ether View Scheme
参考文献
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, , vol. 40, # 8 p. 1077 - 1086
反应条件
1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 72 h / 20 °C / |Glovebox; |UV-irradiation 2: triethylamine / dichloromethane / 0 - 20 °C 3: N-benzyl-aniline / N,N-dimethyl-formamide / 144 h / |Glovebox; |UV-irradiation; |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 2 p. 474 - 478
Angew. Chem., , vol. 126, # 2 p. 484 - 488,5
反应条件
1.1: water / 150 °C / |Green chemistry 2.1: triethylamine / dichloromethane / 0.17 h / |Inert atmosphere; |Cooling with ice 2.2: 25 °C / |Inert atmosphere; |Cooling with ice View Scheme
参考文献
Green Chemistry, , vol. 16, # 4 p. 2147 - 2155
反应条件
1.1: water / 0.33 h / 150 °C / |Green chemistry 2.1: triethylamine / dichloromethane / 0.17 h / |Inert atmosphere; |Cooling with ice 2.2: 25 °C / |Inert atmosphere; |Cooling with ice View Scheme
参考文献
Green Chemistry, , vol. 16, # 4 p. 2147 - 2155
