(1H-咪唑-4-基)甲胺盐酸盐合成路线 （共 4 条）
反应条件
1: With ammonia; Raney nickel in methanol
T=40°C; 0.5 h;
2: With hydrogen in methanol
T=40 - 50°C; P=3750.38 Torr; 28 h;
3: With hydrogenchloride in methanol; diethyl ether
参考文献
Dahmann, Georg; Gerlach, Kai; Pfau, Roland; Priepke, Henning; Wienen, Wolfgang; Schuler-Metz, Annette; Nar, Herbert
Patent: US2008/51578 A1, 2008 ;
Location in patent: Page/Page column 34 ;
反应条件
hydrogenchloride; hydrogen; palladium 10 on activated carbon in tetrahydrofuran; ethanol; ethyl acetate
T=80°C; P=4500.45 Torr; 3 h;
参考文献
GALDERMA RESEARCH andamp; DEVELOPMENT; BOUIX-PETER, Claire; SUZUKI, Itaru; PELISSON, Isabelle; COLLETTE, Pascal; TABET, Samuel; LAFITTE, Guillaume
Patent: WO2010/52255 A1, 2010 ;
Location in patent: Page/Page column 68 ;
WO 2010/052255 A1
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
P=49400 Torr;
参考文献
Sugiyama, Toru; Ohno, Masaji; Shibasaki, Masakatsu; Otsuka, Masami; Sugiura, Yukio; et al.
Heterocycles, 1994 , vol. 37, # 1 p. 275 - 282
反应条件
hydrogenchloride; palladium on activated charcoal
Hydration;
参考文献
Turner et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2801
