(2-溴-5-甲氧基苯基)丙酸合成路线 （共 8 条）
反应条件
1: polyphosphoric acid / 1 h / 60 °C 2: sodium acetate; hydrogen; palladium 10 on activated carbon / ethanol / 3040.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 920 - 930
反应条件
bromine in dichloromethane
T=0°C; 0.25 h;
参考文献
Meyer; DeBernardis; Hancock
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 105 - 112
反应条件
2: tetrachloromethane; bromine / -10 °C
View Scheme
参考文献
Barnes; Kraft; Gordon
Journal of the American Chemical Society, 1949 , vol. 71, p. 3523,3527
反应条件
formic acid; triethylamine
T=0 - 100°C; 4 h;
参考文献
Pflaesterer, Daniel; Rettenmeier, Eva; Schneider, Severin; De Las Heras Ruiz, Edgar; Rudolph, Matthias; Hashmi, A. Stephen K.
Chemistry - A European Journal, 2014 , vol. 20, # 22 p. 6752 - 6755
反应条件
1: ethanol
2: (i) KOH, EtOH, (ii) (decarboxylation)
View Scheme
参考文献
UCB S.A.
Patent: DE2733868 , 1978 ;
Chem.Abstr., 1978 , vol. 88, # 152456
反应条件
(i) KOH, EtOH, (ii) (decarboxylation); Multistep reaction;
参考文献
UCB S.A.
Patent: DE2733868 , 1978 ;
Chem.Abstr., 1978 , vol. 88, # 152456
反应条件
1: polyphosphoric acid / 1 h / 60 °C
2: sodium acetate; hydrogen; palladium 10 on activated carbon / ethanol / 3040.2 Torr
3: hydrogenchloride; sodium azide / water / 0 - 20 °C
View Scheme
参考文献
Abate, Carmen; Selivanova, Svetlana V.; Mueller, Adrienne; Kraemer, Stefanie D.; Schibli, Roger; Marottoli, Roberta; Perrone, Roberto; Berardi, Francesco; Niso, Mauro; Ametamey, Simon M.
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 920 - 930
参考文献
Meyer; DeBernardis; Hancock
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 105 - 112
