6-氯-2-甲硫基-7H-嘌呤合成路线 （共 6 条）
反应条件
N,N-diethylaniline; trichlorophosphate 1.5 h; Reflux;
参考文献
Szucova, Lucie; Krystof, Viadimir; Zatloukal, Marek; Dolezal, Karel; Strnad, Miroslav; Spichal, Lukas
Patent: US2012/71433 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1.1: sodium hydroxide / water / 25 - 40 °C 1.2: pH 5 2.1: N,N-diethylaniline; trichlorophosphate / 1.5 h / Reflux View Scheme
反应条件
1.1: formamide / 2 h / 175 - 185 °C 2.1: sodium hydroxide / water / 25 - 40 °C 2.2: pH 5 3.1: N,N-diethylaniline; trichlorophosphate / 1.5 h / Reflux View Scheme
反应条件
potassium carbonate in butan-1-ol T=110°C; 5 h; chemoselective reaction;
参考文献
Corder, Andra L.; Subedi, Bishnu P.; Zhang, Siai; Dark, Amanda M.; Foss Jr., Frank W.; Pierce, Brad S.
Biochemistry, 2013 , vol. 52, # 36 p. 6182 - 6196
参考文献
Noell; Robins
Journal of Organic Chemistry, 1959 , vol. 24, p. 320,321
反应条件
1: methanol; chlorine
2: H2O; ethanol
3: water
View Scheme
参考文献
Noell; Robins
Journal of the American Chemical Society, 1959 , vol. 81, p. 5997,5999,6006
