2,6-二溴-3-羟基吡啶合成路线 （共 17 条）
反应条件
1: 80 percent / Ethylisopropylamine / CH2Cl2 / 4 h / Ambient temperature 2: 1.) 1.55M n-BuLi / 1.) ether, hexane, -78 deg C, 1.5 h, 2.) ether, hexane, 25 deg C, 2.5 h View Scheme
参考文献
Hasseberg, Hans-Albrecht; Gerlach, Hans
Liebigs Annalen der Chemie, 1989 , p. 255 - 262
反应条件
potassium carbonate in dimethyl sulfoxide
1 h; Heating;
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating
2: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C
View Scheme
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating
2: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C
3: 44 percent / H2 / platinum oxide / ethanol / 760 Torr
View Scheme
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating
2: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C
3: 95 percent / sodium methoxide / methanol / 20 h
View Scheme
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating
2: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C
3: 95 percent / sodium methoxide / methanol / 20 h
4: hydrazine hydrate / Pd/C / ethanol / 0.5 h / Heating
View Scheme
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: With iodine; sodium hydrogencarbonate in water
T=20°C; 120 h;
2: With hydrogenchloride in water
pH=2;
参考文献
Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David
Patent: US2013/53372 A1, 2013 ;
Location in patent: Paragraph 0597; 0598; 0599 ;
