反应条件
1.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 17.5 h / 0 - 50 °C / |Inert atmosphere 2.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / |Inert atmosphere 3.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C 3.2: 12 h / -78 - 20 °C View Scheme
参考文献
AMGEN INC.; BISWAS, Kaustav; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; MA, Vu Van; SHAM, Kelvin; ZHONG, Wenge
Patent: US2014/45855 A1, 2014 ;