3-羟基吡啶-N-氧化物合成路线 （共 22 条）
反应条件
sodium hydroxide; bromine 24 h; Title compound not separated from byproducts;
参考文献
Tiecco; Tingoli; Testaferri; et al.
Tetrahedron, 1986 , vol. 42, # 5 p. 1475 - 1485
反应条件
1: sulfuric acid; nitric acid 2: chloroform; phosphorus (III)-chloride View Scheme
参考文献
Lewicka; Plazek
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 644,646
反应条件
1: sulfuric acid; nitric acid 2: chloroform; phosphorus (III)-bromide View Scheme
参考文献
Lewicka; Plazek
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 644,646
反应条件
1: 65 percent 2: 85 percent / HNO3, NO2, H2SO4 3: 77 percent / CH3COBr 4: 80 percent / Fe, HOAc View Scheme
参考文献
Swindell, Charles S.; Duffy, Ruth H.
Heterocycles, 1986 , vol. 24, # 12 p. 3373 - 3377
反应条件
methyloxorhenium(V)(2-(mercaptomethyl)thiophenolate) triphenylphosphine; triphenylphosphine in benzene T=20°C; 7 h;
参考文献
Wang, Ying; Espenson, James H.
Organic Letters, 2000 , vol. 2, # 22 p. 3525 - 3526
参考文献
Heterocycles, , vol. 24, # 12 p. 3373 - 3377
反应条件
1: 1.) Br2; 2.) NaOCH3 / 1.) 10percent aq. NaOH, 24 h; 2.) MeOH, DMF, RT, 1.5 h
2: 48 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C
3: 78 percent / NaOCH3 / methanol / 2 h / Ambient temperature
4: 85 percent / PBr3 / CHCl3 / 0.5 h / 60 °C
5: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
6: 85 percent / m-chloroperbenzoic acid / CHCl3 / 8 h / Ambient temperature
7: 60 percent / 48percent aq. HBr / 5 h / 120 °C
View Scheme
参考文献
Tiecco; Tingoli; Testaferri; et al.
Tetrahedron, 1986 , vol. 42, # 5 p. 1475 - 1485
反应条件
1: 1.) Br2; 2.) NaOCH3 / 1.) 10percent aq. NaOH, 24 h; 2.) MeOH, DMF, RT, 1.5 h
2: 48 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C
3: 78 percent / NaOCH3 / methanol / 2 h / Ambient temperature
4: 85 percent / PBr3 / CHCl3 / 0.5 h / 60 °C
5: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
View Scheme
参考文献
Tiecco; Tingoli; Testaferri; et al.
Tetrahedron, 1986 , vol. 42, # 5 p. 1475 - 1485
反应条件
1: 1.) Br2; 2.) NaOCH3 / 1.) 10percent aq. NaOH, 24 h; 2.) MeOH, DMF, RT, 1.5 h
2: 48 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C
3: 78 percent / NaOCH3 / methanol / 2 h / Ambient temperature
4: 85 percent / PBr3 / CHCl3 / 0.5 h / 60 °C
5: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
6: 85 percent / m-chloroperbenzoic acid / CHCl3 / 8 h / Ambient temperature
View Scheme
参考文献
Tiecco; Tingoli; Testaferri; et al.
Tetrahedron, 1986 , vol. 42, # 5 p. 1475 - 1485
反应条件
1: 1.) Br2; 2.) NaOCH3 / 1.) 10percent aq. NaOH, 24 h; 2.) MeOH, DMF, RT, 1.5 h
2: 48 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C
3: 78 percent / NaOCH3 / methanol / 2 h / Ambient temperature
4: 85 percent / PBr3 / CHCl3 / 0.5 h / 60 °C
5: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
6: 85 percent / m-chloroperbenzoic acid / CHCl3 / 8 h / Ambient temperature
7: 60 percent / 48percent aq. HBr / 5 h / 120 °C
8: 50 percent / 220 °C / 0.01 Torr / sublimation
View Scheme
参考文献
Tiecco; Tingoli; Testaferri; et al.
Tetrahedron, 1986 , vol. 42, # 5 p. 1475 - 1485
