2,4-二氯-6-吗啉基-1,3,5-三嗪合成路线 （共 8 条）
反应条件
triethylamine in acetone T=5°C;
参考文献
US2007/244110 A1, ;
Page/Page column 4 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=-78°C; 0.166667 h;
参考文献
US2008/58297 A1, ;
Page/Page column 37; 39 ;
反应条件
in tetrahydrofuran T=0°C; Inert atmosphere;
参考文献
Australian Journal of Chemistry, , vol. 64, # 11 p. 1430 - 1437
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
US2007/244110 A1, ;
Page/Page column 4 ;
反应条件
1: 4,6-dichloro-N-morpholinyl-1,3,5-triazine-2-amine; 2-(difluoromethyl)-1H-benzo[d]imidazole With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 16 h; 2: 2,4,6-trichloro-pyrimidine in DMF (N,N-dimethyl-formamide) T=20°C; 1.5 h;
参考文献
EP1389617 A1, ;
Page 12 ;
反应条件
potassium carbonate in tetrahydrofuran T=20°C; 3 h;
参考文献
Manohar, Sunny; Khan, Shabana I.; Rawat, Diwan S.
Chemical Biology and Drug Design, 2013 , vol. 81, # 5 p. 625 - 630
反应条件
potassium carbonate in tetrahydrofuran T=20°C; 3 h;
参考文献
Manohar, Sunny; Pepe, Antonella; Velez Gerena, Christian E.; Zayas, Beatriz; Malhotra, Sanjay V.; Rawat, Diwan S.
RSC Advances, 2014 , vol. 4, # 14 p. 7062 - 7067
反应条件
sodium carbonate in water; acetone
T=35 - 45°C;
参考文献
Kumar, Nitin; Khan, Shabana I.; Rawat, Diwan S.
Helvetica Chimica Acta, 2012 , vol. 95, # 7 p. 1181 - 1197
