2-氨基-3,5-二氢吡咯并[3,2-D]嘧啶-4-酮合成路线 （共 16 条）
反应条件
ammonium formate; palladium 10 on activated carbon in methanol T=75°C; 4 h;
参考文献
VALEANT RESEARCH and DEVELOPMENT
Patent: WO2006/122003 A2, 2006 ;
Location in patent: Page/Page column 32; 36 ;
WO 2006/122003 A2
反应条件
sodium dithionite in water Cyclization; reduction; elimination; 2 h; Heating;
参考文献
Industrial Research Limited; Albert Einstein College of Medicine of Yesheva University
Patent: US6693193 B1, 2004 ;
Location in patent: Page column 11-12; 16 ;
反应条件
hydrogen; palladium dihydroxide in methanol P=2585.74 Torr; 5 h;
参考文献
Liu, Mao-Chin; Luo, Mei-Zhen; Mozdziesz, Diane E.; Sartorelli, Alan C.
Synthetic Communications, 2002 , vol. 32, # 24 p. 3797 - 3802
反应条件
1: With triethylamine; mercury dichloride in N,N-dimethyl-formamide T=26°C; 2: With sodium acetate in methanol T=0 - 20°C; 3: With sodium hydroxide in methanol; water T=60°C; 0.5 h;
参考文献
HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian
Patent: WO2011/35009 A1, 2011 ;
Location in patent: Page/Page column 74-75 ;
反应条件
sodium hydroxide in ethanol
参考文献
Taylor, Edward C.; Young, Wendy B.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7947 - 7952
反应条件
1: 90 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 2 h / 20 °C 2: 91 percent / dimethylformamide / 40 h / 20 °C 3: 95 percent / sodium hydrogen sulfite / tetrahydrofuran; H2O / 12 h / 20 °C 4: 95 percent / ammonia / ethanol / 4 h / 165 - 170 °C 5: 90 percent / hydrogen / palladium(II) hydroxide on carbon / methanol / 5 h / 2585.74 Torr View Scheme
参考文献
Synthetic Communications, , vol. 32, # 24 p. 3797 - 3802
反应条件
1: 80 percent / dimethylformamide / 24 h / 100 °C 2: 61 percent / sodium dithionite / H2O / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 22 p. 8411 - 8412
反应条件
1: 91 percent / dimethylformamide / 40 h / 20 °C 2: 95 percent / sodium hydrogen sulfite / tetrahydrofuran; H2O / 12 h / 20 °C 3: 95 percent / ammonia / ethanol / 4 h / 165 - 170 °C 4: 90 percent / hydrogen / palladium(II) hydroxide on carbon / methanol / 5 h / 2585.74 Torr View Scheme
参考文献
Synthetic Communications, , vol. 32, # 24 p. 3797 - 3802
反应条件
1: 95 percent / ammonia / ethanol / 4 h / 165 - 170 °C 2: 90 percent / hydrogen / palladium(II) hydroxide on carbon / methanol / 5 h / 2585.74 Torr View Scheme
参考文献
Synthetic Communications, , vol. 32, # 24 p. 3797 - 3802
反应条件
1: 95 percent / sodium hydrogen sulfite / tetrahydrofuran; H2O / 12 h / 20 °C 2: 95 percent / ammonia / ethanol / 4 h / 165 - 170 °C 3: 90 percent / hydrogen / palladium(II) hydroxide on carbon / methanol / 5 h / 2585.74 Torr View Scheme
参考文献
Synthetic Communications, , vol. 32, # 24 p. 3797 - 3802
