5-氯噻吩[3,2-B]吡啶合成路线 (共 7 条)
反应条件
1: T=100°C; 0.5 h;
2: With N,N-dimethyl-formamide; trichlorophosphate in 1,2-dichloro-ethane
T=0°C; 16.25 h; Reflux;
3: With sodium acetate in water; 1,2-dichloro-ethane
T=100°C; 0.333333 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157270 A1, 2008 ;
Location in patent: Page/Page column 90-91 ;
反应条件
trichlorophosphate in 1,2-dichloro-ethane
4 h; Heating;
参考文献
Meth-Cohn, Otto; Narine, Brahma; Tarnowski, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1531 - 1536
参考文献
AMERICAN CYANAMID COMPANY
Patent: EP446604 A2, 1991 ;
反应条件
acetic acid; zinc
Ambient temperature;
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David; Keenan, Guy J.; Wright, Brian
Journal of Chemical Research, Miniprint, 1984 , # 3 p. 771 - 795
反应条件
1: 83 percent / m-chloroperoxybenzoic acid / CHCl3 / 96 h / Ambient temperature
2: 17 percent / phosphorus oxychloride / 4 h / Heating
View Scheme
参考文献
Klemm, L. H.; Louris, John N.; Boisvert, William; Higgins, Clay; Muchiri, Daniel R.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1249 - 1252
反应条件
trichlorophosphate
4 h; Heating;
参考文献
Klemm, L. H.; Louris, John N.; Boisvert, William; Higgins, Clay; Muchiri, Daniel R.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1249 - 1252
反应条件
dipotassium hydrogenphosphate; bromine; sodium hydrogencarbonate; magnesium sulfate in chloroform
Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/107784 A1, 2006 ;
Location in patent: Page/Page column 104-105 ;
WO 2006/107784 A1