1,3-二甲基-1,3-二氢-2H-咪唑-2-硫酮合成路线 （共 14 条）
反应条件
sulfur; 1,8-diazabicyclo[5.4.0]undec-7-ene in pyridine; methanol
T=65 - 68°C; 6 h; var. base: DBN, K2CO3, var. temp.;
参考文献
Karkhanis, Dattatraya W.; Field, Lamar
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 22, p. 49 - 58
反应条件
n-butyllithium; sulfur dioxide
1.)hexane, CH2Cl2, -78 deg C, 10-20 min; 2.) (C2H5)2O, -78 deg C, 1 h, room temp., 20 h; Yield given. Multistep reaction;
参考文献
Zoller, Uri
Tetrahedron, 1988 , vol. 44, # 24 p. 7413 - 7426
反应条件
1: formaldehyd; ethylamine in water
0.5 h; Cooling with ice;
2: ethane-1,2-dial; acetic acid; methylamine in water
T=0 - 20°C; 36 h;
3: With sulfur
24 h;
参考文献
Rodriguez, Hector; Gurau, Gabriela; Holbrey, John D.; Rogers, Robin D.
Chemical Communications, 2011 , vol. 47, # 11 p. 3222 - 3224
反应条件
sodium hydrogensulfite in methanol
5 h; Irradiation;
参考文献
Iwasaki, Shigeo
Heterocycles, 1982 , vol. 17, p. 125 - 138
反应条件
Multistep reaction.;
参考文献
Wolfe, Derek M.; Schreiner, Peter R.
European Journal of Organic Chemistry, 2007 , # 17 p. 2825 - 2838
反应条件
n-butyllithium
1.)hexane, CH2Cl2, -78 deg C, 10-20 min; 2.) CH2Cl2, -78 deg C, 1 h, room temp., 18 h; Yield given. Multistep reaction;
参考文献
Zoller, Uri
Tetrahedron, 1988 , vol. 44, # 24 p. 7413 - 7426
反应条件
n-butyllithium
1.)hexane, CH2Cl2, -78 deg C, 10-20 min; 2.) THF, -78 deg C, 1 h, room temp., 24 h; Yield given. Multistep reaction;
参考文献
Zoller, Uri
Tetrahedron, 1988 , vol. 44, # 24 p. 7413 - 7426
反应条件
potassium carbonate
2.) methanol; Multistep reaction;
参考文献
Suszka, Andrzej
Polish Journal of Chemistry, 1980 , vol. 54, # 11/12 p. 2289 - 2296
反应条件
n-butyllithium
1.)hexane, CH2Cl2, -78 deg C, 10-20 min; 2.) THF, -78 deg C, 1 h, room temp., 96 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Zoller, Uri
Tetrahedron, 1988 , vol. 44, # 24 p. 7413 - 7426
反应条件
n-butyllithium
1.)hexane, CH2Cl2, -78 deg C, 10-20 min; 2.) CH2Cl2, -78 deg C, 1 h, room temp., 28 h; Yield given. Multistep reaction;
参考文献
Zoller, Uri
Tetrahedron, 1988 , vol. 44, # 24 p. 7413 - 7426
