2-(叔-丁基硫代)苯甲醛合成路线 （共 9 条）
反应条件
1: 2-methylpropane-2-thiol With sodium hydride in N,N-dimethyl-formamide T=0°C; Inert atmosphere; 2: 2-chloro-benzaldehyde in N,N-dimethyl-formamide T=20°C;
参考文献
Angewandte Chemie, International Edition, , vol. 48, # 38 p. 7064 - 7068
Angewandte Chemie, , vol. 121, # 38 p. 7198 - 7202
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 96 h;
参考文献
Journal of Organometallic Chemistry, , vol. 693, # 12 p. 2200 - 2203
反应条件
potassium hydroxide in water; dimethyl sulfoxide; ethyl acetate
反应条件
potassium carbonate in N,N-dimethyl-formamide 30 h, 100 deg C, then 12 h, room temperature;
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 2 p. 711 - 714
反应条件
1: 75 percent / LiTMP / tetrahydrofuran / -78 °C 2: 1.) t-BuLi/TMEDA / 1.) THF, -78 deg C 3: 1.) TBAF 2.) Et3BHLi / 1.) THF, RT 2.) THF, from -20 to 0 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 43 p. 5841 - 5844
反应条件
in N,N-dimethyl-formamide T=-30°C; 7 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 85, # 5 p. 613 - 623
反应条件
tetrabutyl ammonium fluoride; lithium triethylborohydride 1.) THF, RT 2.) THF, from -20 to 0 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 30, # 43 p. 5841 - 5844
反应条件
1: 1.) t-BuLi/TMEDA / 1.) THF, -78 deg C 2: 1.) TBAF 2.) Et3BHLi / 1.) THF, RT 2.) THF, from -20 to 0 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 43 p. 5841 - 5844
反应条件
1.1: 88 percent / boron trifluoride etherate; acetic acid / toluene
2.1: titanocene dichloride; magnesium; triethyl phosphite / tetrahydrofuran / 0.25 h
2.2: 41 percent / tetrahydrofuran
3.1: 67 percent / TFA / 2 h / 20 °C
View Scheme
参考文献
Roberts, Christine F.; Hartley, Richard C.
Journal of Organic Chemistry, 2004 , vol. 69, # 18 p. 6145 - 6148
