1-[(2S)-吡咯烷甲基]哌啶合成路线 （共 12 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
3 h; Heating;
参考文献
Mukaiyama, Teruaki; Kobayashi, Shu; Sano, Tetsuya
Tetrahedron, 1990 , vol. 46, # 13/14 p. 4653 - 4662
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
4 h; Heating;
参考文献
Amedjkouh, Mohamed; Ahlberg, Per
Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2229 - 2234
反应条件
lithium in tetrahydrofuran; ethanol; ammonia
0.25 h; Heating;
参考文献
Hendrie, Shirley K.; Leonard, John
Tetrahedron, 1987 , vol. 43, # 14 p. 3289 - 3294
反应条件
1: H2 / 5percent Pd/C / methanol
2: LiAlH4 / tetrahydrofuran / 20 h / Heating
View Scheme
参考文献
Asami
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 721 - 727
反应条件
1: 1) DCC / 1) CH2Cl2, 0 deg C, 30 min, 2) a) 0 deg C to r.t., b) r.t., overnight
2: H2 / 5percent Pd/C / methanol
3: LiAlH4 / tetrahydrofuran / 20 h / Heating
View Scheme
参考文献
Asami
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 721 - 727
反应条件
1: 1) DCC / 1) CH2Cl2, 0 deg C, 30 min, 2) a) 0 deg C to r.t., b) r.t., overnight
2: H2 / 5percent Pd/C / methanol
3: LiAlH4 / tetrahydrofuran / 20 h / Heating
View Scheme
参考文献
Asami
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 721 - 727
反应条件
1: 65 percent / triethylamine / CH2Cl2 / 24 h / Heating
2: 75 percent / DBU / toluene / 24 h / Heating
3: 75 percent / lithium / tetrahydrofuran; ethanol; liquid ammonia / 0.25 h / Heating
View Scheme
参考文献
Hendrie, Shirley K.; Leonard, John
Tetrahedron, 1987 , vol. 43, # 14 p. 3289 - 3294
反应条件
1: 91 percent / PTSA / toluene / 16 h / Heating
2: 93 percent / acetonitrile / 0.17 h / 20 °C
3: 88 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Amedjkouh, Mohamed; Ahlberg, Per
Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2229 - 2234
反应条件
1: 93 percent / acetonitrile / 0.17 h / 20 °C
2: 88 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Amedjkouh, Mohamed; Ahlberg, Per
Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2229 - 2234
反应条件
1: 75 percent / DBU / toluene / 24 h / Heating
2: 75 percent / lithium / tetrahydrofuran; ethanol; liquid ammonia / 0.25 h / Heating
View Scheme
参考文献
Hendrie, Shirley K.; Leonard, John
Tetrahedron, 1987 , vol. 43, # 14 p. 3289 - 3294
