2,5-二氮杂双环[2.2.2]辛烷合成路线 (共 1 条)
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
16 h; Heating / reflux;
2: With sodium hydroxide; water in tetrahydrofuran
T=20°C; 1 h;
参考文献
PANACOS PHARMACEUTICALS, INC.; NITZ, Theodore, J.; SALZWEDEL, Karl; FINNEGAN, Catherine; WILD, Carl; BRUNTON, Shirley; FLANAGAN, Stuart; MONTALBETTI, Christian; COULTER, Thomas, Stephen; KIMBER, Marc; MAGARACI, Filippo; JOHNSTON, David
Patent: WO2008/134035 A1, 2008 ;
Location in patent: Page/Page column 195-196 ;