2-(4-乙基氨基-苯基)-1,1,1,3,3,3-六氟-2-丙醇合成路线 （共 5 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=20°C; 22 h;
2: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 16 h;
参考文献
Orphagen Pharmaceuticals; Thacher, Scott; Li, Xiaolin; Babine, Robert; Tse, Bruno
Patent: US8389739 B1, 2013 ;
Location in patent: Page/Page column 30 ;
US 8389739 B1
参考文献
Panday, Narendra; Benz, Joerg; Blum-Kaelin, Denise; Bourgeaux, Vanessa; Dehmlow, Henrietta; Hartman, Peter; Kuhn, Bernd; Ratni, Hassen; Warot, Xavier; Wright, Matthew B.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5231 - 5237
反应条件
in chloroform
T=20°C; 1 h;
参考文献
Zelenin, A. E.; Chkanikov, N. D.; Galakhov, M. V.; Kolomiets, A. F.; Fokin, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985 , vol. 34, # 4 p. 850 - 853
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985 , # 4 p. 931 - 934
反应条件
1.1: Py
1.2: aq. NaOH
2.1: 96 percent / BH3*THF
View Scheme
参考文献
Panday, Narendra; Benz, Joerg; Blum-Kaelin, Denise; Bourgeaux, Vanessa; Dehmlow, Henrietta; Hartman, Peter; Kuhn, Bernd; Ratni, Hassen; Warot, Xavier; Wright, Matthew B.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5231 - 5237
反应条件
in chloroform
T=20°C; 1440 h; Mechanism;
参考文献
Chkanikov, N. D.; Vershinin, V. L.; Galakhov, M. V.; Kolomiets, A. F.; Fokin, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989 , vol. 38, # 1.2 p. 113 - 119
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989 , vol. 38, # 1 p. 126 - 132
