6,7,8,9-四氢-5H-咔唑-3-胺合成路线 （共 6 条）
反应条件
1: With ethanol; water; tin(ll) chloride T=70°C; 16 h; 2: With sodium hydrogencarbonate in ethanol; water
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 122 ;
反应条件
sodium hydrogencarbonate in ethanol
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 1) acetic acid, Naac, 2) HCl / 1) H2O, ethanol, reflux, 3 h, 2) acetic acid, reflux, 0.5 h 2: 92 percent / N2H4*H2O / Raney-Ni / ethanol / Heating View Scheme
参考文献
Pharmazie, , vol. 48, # 11 p. 817 - 820
反应条件
1: 1) acetic acid, Naac, 2) HCl / 1) H2O, ethanol, reflux, 3 h, 2) acetic acid, reflux, 0.5 h 2: 92 percent / N2H4*H2O / Raney-Ni / ethanol / Heating View Scheme
参考文献
Pharmazie, , vol. 48, # 11 p. 817 - 820
参考文献
Yuki Gosei Kagaku Kyokaishi, , vol. 12, p. 29,34
Chem.Abstr., , p. 723
反应条件
1: concentrated sulfuric acid; potassium nitrate / -5 - -3 °C 2: iron powder; diluted hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , vol. 119, p. 1836
Journal of the Chemical Society, , vol. 123, p. 676
