2,6-二氯-N-羟基-氯代苯甲醛肟合成路线 （共 21 条）
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide T=20°C;
参考文献
Phenex Pharmaceuticals AG
Patent: EP2289883 A1, 2011 ;
Location in patent: Page/Page column 12; 16 ;
EP 2289883 A1
反应条件
N-chloro-succinimide in DMF (N,N-dimethyl-formamide) T=40 - 50°C; 0.5 h;
参考文献
WO2005/82898 A1, ;
Page/Page column 61 ;
反应条件
N-chloro-succinimide in water; N,N-dimethyl-formamide
反应条件
1: With hydroxylamine 2: With N-chloro-succinimide
参考文献
WO2004/99165 A2, ;
Page 6/84 ;
反应条件
N-ethyl-N,N-diisopropylamine 24 h;
参考文献
4SC Discovery GmbH
Patent: US2012/196862 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
triethylamine in tetrahydrofuran T=20 - 67°C; 4 h;
参考文献
Easton; Heath; Hughes; Lee; Savage; Simpson; Tiekink; Vuckovic; Webster
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 10 p. 1168 - 1174
反应条件
1: NaOMe / methanol / 20 °C 2: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
1.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 1.2: 2 h / 0 - 20 °C / pH 9 2.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux 3.1: phosphorus pentachloride / 1 h / 45 °C View Scheme
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
triethylamine in dichloromethane T=0 - 5°C;
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
反应条件
triethylamine; 1-methyl-3-phenyl-1,2,4-triazin-6(1H)-one in dichloromethane T=0 - 20°C; Elimination; cyclodimerization;
参考文献
Collins, David J.; Hughes, Timothy C.; Johnson, Wynona M.
Australian Journal of Chemistry, 2000 , vol. 53, # 2 p. 137 - 141
