3-硝基-2,2,2-三氟苯乙酮合成路线 （共 14 条）
反应条件
sodium nitrate; sulfuric acid T=0°C; 1 h;
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 89; 90 ;
反应条件
oxygen; iron(III) chloride; nitrogen(IV) oxide; ozone in dichloromethane T=-10 - 0°C; 1 h; Yields of byproduct given;
参考文献
Suzuki; Tatsumi; Maeda
Synthesis, 1995 , # 11 p. 1353 - 1354
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(I) thiophene-2-carboxylate; trifuran-2-yl-phosphane in tetrahydrofuran T=50°C; 18 h;
参考文献
Liebeskind; Srogl
Journal of the American Chemical Society, 2000 , vol. 122, # 45 p. 11260 - 11261
反应条件
Pd2(dba)3*CHCl3/tris(2-furyl)phosphine in tetrahydrofuran addn. of 1.6 equiv. of C4H3SCOOCu to the reaction of CF3COSC6H4CH3 (1 equiv.) with (NO2C6H4)B(OH)2 (1 equiv.) in THF in presence of 1percent Pd2(dba)3*CHCl3/(tris-2-furylphosphine), holding for 18 h at 50°C;
参考文献
Liebeskind; Srogl
Journal of the American Chemical Society, 2000 , vol. 122, # 45 p. 11260 - 11261
反应条件
bis(trifluoromethyl)cadmium*glyme in pyridine T=0°C; 8 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 56, # 2 p. 215 - 237
反应条件
2,6-dimethylpyridine; oxoammonium salt in dichloromethane T=20°C; Sealed tube;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
in pyridine T=0°C; 8 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 56, # 2 p. 215 - 237
反应条件
1.1: tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere; |Sealed tube 1.2: 0 - 20 °C / |Inert atmosphere; |Sealed tube 1.3: 0 - 20 °C / |Inert atmosphere; |Sealed tube 2.1: oxoammonium salt; 2,6-dimethylpyridine / dichloromethane / 20 °C / |Sealed tube View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 18 p. 8131 - 8141
反应条件
1.1: pyridine / dichloromethane / 0 - 20 °C 2.1: cesium fluoride / toluene / 0.17 h / 0 °C 2.2: 24 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 48, # 77 p. 9610 - 9612
反应条件
T=0°C; 8 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 56, # 2 p. 215 - 237
