hydrogen; chiral rhodium binaphthyl-based phosphoramidite in 2,2,2-trifluoroethanol T=20°C; P=3750.3 Torr; 24 h; Title compound not separated from byproducts;

1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate in isopropyl alcohol Heck arylation; 8 h; Heating;

iron; acetic acid in toluene T=75°C; 5 h; Inert atmosphere;

1: hydroxylamine hydrochloride 2: iron; acetic acid / toluene / 5 h / 75 °C / Inert atmosphere View Scheme

1: With potassium carbonate; palladium diacetate; 1,3-bis-(diphenylphosphino)propane in water; N,N-dimethyl-formamide T=120°C; 16 h; Pressure bottle; 2: With potassium carbonate in water 0.5 h; Product distribution / selectivity;