4-氧代-1,2,3,4-四氢萘-2-羧酸合成路线 （共 23 条）
参考文献
v. Braun
Chemische Berichte, 1928 , vol. 61, p. 443
反应条件
1: With α-ethylbenzylamine in methanol 2: With hydrogenchloride in water
参考文献
SmithKline Beecham SpA
Patent: US2004/24218 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
1: With α-ethylbenzylamine in methanol 2: With hydrogenchloride in water
参考文献
US2004/24218 A1, ;
Page 9 ;
反应条件
sulfuric acid in water
T=60°C; 0.333333 h;
参考文献
Sher, Philip M.; Nirschl, Alexandra A.; Meng, Wei; Washburn, William N.
Patent: US2006/111338 A1, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
potassium hydroxide in water
参考文献
Bristol-Myers Squibb Company
Patent: US5739135 A1, 1998 ;
反应条件
1: With sodium hydroxide in ethanol; water
1 h; Heating / reflux;
2: With hydrogenchloride in water
3: With sulfuric acid
more than 3 stages;
参考文献
SmithKline Beecham SpA
Patent: US2004/24218 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
1: NaOH / methanol / 12 h / Heating
2: 98 percent / H2; acetic acid / 10 percent Pd/C / 3 h / 75 °C
3: 73 percent / H2SO4 / 8 h / 20 °C
View Scheme
参考文献
Caro, Yolanda; Masaguer, Christian F.; Ravina, Enrique
Tetrahedron Asymmetry, 2003 , vol. 14, # 3 p. 381 - 387
反应条件
1: t-BuOK / 2-methyl-propan-2-ol / Heating
2: NaOH / methanol / 12 h / Heating
3: 98 percent / H2; acetic acid / 10 percent Pd/C / 3 h / 75 °C
4: 73 percent / H2SO4 / 8 h / 20 °C
View Scheme
参考文献
Caro, Yolanda; Masaguer, Christian F.; Ravina, Enrique
Tetrahedron Asymmetry, 2003 , vol. 14, # 3 p. 381 - 387
反应条件
ammonia; iron(III) chloride; lithium in tetrahydrofuran
0.5 h; Yield given;
参考文献
Murthy, A. Radhakrishna; Sundar, N. Shyama; Rao, G. S. R. Subba
Tetrahedron, 1982 , vol. 38, # 18 p. 2831 - 2836
反应条件
1: 98 percent / H2; acetic acid / 10 percent Pd/C / 3 h / 75 °C
2: 73 percent / H2SO4 / 8 h / 20 °C
View Scheme
参考文献
Caro, Yolanda; Masaguer, Christian F.; Ravina, Enrique
Tetrahedron Asymmetry, 2003 , vol. 14, # 3 p. 381 - 387
