(S)-4-羟基-5-甲基-2-己酮合成路线 （共 11 条）
反应条件
1: pyridine 2: KOtBu / 2-methyl-propan-2-ol View Scheme
参考文献
Muir,D.M.; Parker,A.J.
Journal of Organic Chemistry, 1976 , vol. 41, p. 3201 - 3204
反应条件
toluene-4-sulfonic acid in 1,4-dioxane T=110°C; 0.0130556 h;
参考文献
Tanaka, Katsunori; Motomatsu, Shinya; Koyama, Koichi; Tanaka, Shin-Ichi; Fukase, Koichi
Organic Letters, 2007 , vol. 9, # 2 p. 299 - 302
反应条件
sulfuric acid Heating;
参考文献
Muir,D.M.; Parker,A.J.
Journal of Organic Chemistry, 1976 , vol. 41, p. 3201 - 3204
参考文献
Heilmann et al.
Bulletin de la Societe Chimique de France, 1957 , p. 119,122
反应条件
sodium hydroxide
T=20°C;
参考文献
Tanaka, Katsunori; Fukase, Koichi
Organic Process Research and Development, 2009 , vol. 13, # 5 p. 983 - 990
反应条件
hydrogenchloride in water; acetone
参考文献
Nippon Soda Co., Ltd.
Patent: US5300654 A1, 1994 ;
反应条件
zirconium tetra-t-butoxide in tetrahydrofuran
T=-20°C; 1.16667 h;
参考文献
Schneider, Christoph; Hansch, Markus; Weide, Timo
Chemistry - A European Journal, 2005 , vol. 11, # 10 p. 3010 - 3021
反应条件
1: With sodium hydroxide in water
T=60°C; 0.833333 h; Heating / reflux;
2: in water
T=17°C; pH=7; buffer; Product distribution / selectivity;
参考文献
Barnicki, Scott Donald; McCusker-Orth, Jennifer Ellen; Miller, Jerry Lynn
Patent: US2005/4401 A1, 2005 ;
Location in patent: Page 15; 16 ;
反应条件
trimethylaluminum; 1,1'-binaphthyl-2,2'-diol in dichloromethane
T=20°C; 22 h;
参考文献
Simpura, Ilkka; Nevalainen, Vesa
Angewandte Chemie (International Edition in English), 2000 , vol. 39, # 19 p. X3422-3425
反应条件
potassium tert-butylate in tetrahydrofuran
T=0°C; 3 h; Product distribution; Further Variations:Reagentstime;
参考文献
Schneider, Christoph; Hansch, Markus; Weide, Timo
Chemistry - A European Journal, 2005 , vol. 11, # 10 p. 3010 - 3021
